Protocol for Autism Spectrum Disorders

 Dear parent or guardian:

Due to the unique needs of patients with diagnoses in the Autism Spectrum, the Pfeiffer Treatment Center has developed an advanced protocol that addresses each patient’s needs with individualized testing and treatment. This protocol goes above and beyond the standard process described in our general introductory materials.

A recent study conducted at our Center showed approximately 99% of our autism spectrum patients (n=503) exhibited a metal metabolism disorder. Our research has led us to the conclusion that most of these patients have defective functioning of metallothionein protein (MT). A disabled MT protein results in extreme sensitivity to toxic metals, copper elevation and zinc depletion, incomplete maturation of the GI tract, imbalance of immune function, and aberrations in brain neuronal growth and myelin sheath development.

Our advanced treatment protocol for Autism Spectrum patients has been structured specifically to address these aspects of a dysfunctional MT system. Our testing process allows us to develop a complete picture of the interrelationship between metallothionein protein, G.I. function, toxic and trace metals, diet and other factors affecting brain chemistry. 

Prior to the initial appointment, the parent completes an application for treatment, which includes a health history. In order to gain a full understanding of the patient’s response to previous therapies, we ask that parents bring previous testing and interventions, as well as any current medications or supplements being taken to the Initial Appointment.
 

PHASE I MT Induction

The initial visit includes a detailed interview and history, physical examination and laboratory testing, which include toxic and trace metals (an indirect indicator of metallothionein function), methylation markers and kryptopyrroles. Depending on symptoms additional testing may include serum ceruloplasmin delayed food sensitivity profile, comprehensive digestive stool analysis, urine organic acids, urinary peptides and platelet catecholamines. At the initial visit, Phase I treatment is initiated: the system is prepared for intensive nutrient therapy with our Metabolic Primer that gently begins the detoxification process, and stimulates metallothionein formation. Our staff will also make recommendations for dietary modifications, environmental controls, and prescribe supplements to enhance G.I. function. 
 

PHASE II MT Promotion

Phase II of treatment begins after 4-6 weeks of the Phase I metabolic primer therapy. A results consultation is scheduled with a nurse to review the findings of the initial evaluation and the Phase I treatment recommendations. Individualized supplement therapy is prescribed to address specific biochemical imbalances and to promote MT function. Depending on the findings and medical diagnosis, treatment may include initiation of heavy metal detoxification, reduction of copper overload, supportive therapy for the liver, adrenals or other organ systems, and/or treatment of specific causes of GI tract dysfunction. Consultation with our staff Registered Dietician may also be included. 

During the treatment process, parents are encouraged to keep written records of progress. Additional consultations with the nurse, physician assistant, physician or dietician may be scheduled between visits as needed to provide support and guidance.
 

PHASE III Fine Tuning

A follow-up appointment is scheduled approximately 4 months after the initial visit. This visit includes updating the medical history and performing follow-up testing to check progress on imbalances in metal-metabolism, methylation and G.I. function that were identified during the initial visit. Depending on the patient’s progress and symptoms, additional testing may be recommended and could include amino acid analysis, essential fatty acid analysis, immune function markers, myelein basic protein, antibody titers (viruses, immunizations and myelin basic protein) and/or stool and urine follow-up tests.

Our medical staff carefully reviews the results of the follow-up evaluation to design Phase III of the treatment program. Phase III involves the continuation of aggressive MT promotion and fine-tuning of pyrrole chemistry, methylation, GI tract balance, and immune function. Heavy metal detoxification continues. Specific therapies such as Vitamin A/Bethanecol may be recommended. Clinical findings and recommendations are reviewed in consultation with the nurse and physician, either by phone or face-to-face.

Subsequent follow-up visits should be scheduled every 3-6 months depending on progress to further fine-tune the process of correcting MT dysfunction, metal-metabolism disorders, pyrrole chemistry, methylation, G.I. function, detoxification, immune balance and other biochemical disorders. As above, additional testing and treatment options may be recommended depending on the specific needs of the patient.

The unique biochemistry associated with Autism Spectrum disorders is the subject of intensive research and our protocol may change over time to accommodate new knowledge. Please be assured that our goal is always to provide you with the most up-to-date treatment options possible, while taking care to ensure your child’s safety.

Typical Time Line

• Initial Visit: Initiation of Phase I Treatment (Metabolic Primer) 
• 6 Weeks: Start of Phase II therapy (Individualized biochemical balancing including aggressive MT therapy. 
• 4 Months: Follow-Up testing and treatment fine tuning (Phase III)

Sincerely,

The Pfeiffer Center Staff