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Health Research Institute / Pfeiffer Treatment Center The Heath Research Institute / Pfeiffer Treatment Center is committed to advancing research in biochemical disorders and the behavioral, cognitive and metabolic impacts of oxidative stress. Throughout its remarkable 20+ year history, the Health Research Institute / Pfeiffer Treatment Center’s success has been linked to the intimate partnership between its clinical specialist and research staff. Building on this multi decade legacy, its focus has recently turned to the in-depth study of potential biomarkers for autism, as well as exploring immune dysfunction, metallothionein levels and the presence of metallothionein autoantibodies in autistic children. The Health Research Institute has also prioritized investigating the role of autoantibodies in autistic children with GI disease, the role of oxidative stress in cognitive disorders, and the potential relationship between markers for celiac disease and aberrant behavior. Many minds and continuous funding in these research efforts have enabled the Health Research Institute to help support not only their patients through state of the art therapeutic approaches but the researcher community at large; helping to address the challenges that the autism and behavioral disorder community face every single day.
Warrenville, IL 5/5/10- Scientists at the Health Research Institute in conjunction with Pfeiffer Treatment Center have discovered autistic children with gastrointestinal (GI) disease to have low levels of the enzyme, Copper/Zinc Superoxide Dismutase (Cu/Zn SOD). - Click here Warrenville, IL 3/31/10- Tune in as Teri Arranga from Autism One Radio interviews Dr. A.J. Russo, research director of Pfeiffer Treatment Center. AJ's research over the past 7 years has focused on studying Autism. The topics covered include autoimmunity and gastrointestinal disease and biomarkers for GI disease. - Click here Pfeiffer Treatment Center Announces Study Findings That May Help in Gastrointestinal Disease Therapy for Autistic Children Warrenville, IL 2/4/10 – Scientists at the Health Research Institute/Pfeiffer Treatment Center, in collaboration with scientists at the Thoughtful House Center for Children in Austin, Texas have recently discovered autistic children with severe gastrointestinal (GI) disease also have low levels of Hepatocyte Growth Factor (HGF). This year, scientists at Vanderbilt University have confirmed a significant number of autistic children are affected by a defective Met gene. This gene is responsible for making an important protein found in cells in both the brain and gastrointestinal tract known as the C-MET which interacts with HGF to influence nerve cell growth and maturation, and also has an inhibitory effect on GI inflammation. This is one of the first reports showing a specific functional relationship between the Met gene and GI disease seen in many autistic children. Although these results represent preliminary findings, with additional research it is conceivable that low HGF in autistic children may be a marker to help Please click to view the study. - Article
A.J. Russo, Ph.D. Research Director 11/10/09. Scientists at the Health Research Institute/Pfeiffer Treatment Center, in collaboration with scientists at the Thoughtful House Center for Children in Austin, Texas have recently discovered that autistic children with severe gastrointestinal (GI) disease have low but significant levels of different auto antibodies. These antibodies are also found in people with gastrointestinal disorders like Crohn’s Disease and Inflammatory Bowel Disease (IBD). It has long been suspected that autistic children, particularly those with GI disease, are more susceptible to having autoimmune disease, but this is the first report of a relationship between the type and number of these auto antibodies and the severity of the GI disease found in autistic children. The significance of these results includes a possible opportunity to use the identification of these antibodies as a way of categorizing the severity of GI disease and the type of therapy that will be effective at treating the gut. Please click here to view the study. - Article
Reduced Violent Behavior Following Biochemical Therapy- Article Discerning the Mauve Factor (on page 40 of publication) - Article The Autistic Phenotype Exhibits a Remarkably Localized Modification Altered Vascular Phenotype in Autism - Article Elevated Blood Cu and Zn Ratio in Assualtive Young Males - Article
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